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Current classifications of acute leukemia now incorporate a large number of new entities defined by recently described unique genetic drivers. The workshop cases highlighted many of these subtypes and also argued for inclusion of additional entities in future classifications, including KMT2A -rearranged B-ALL/LBL with surface light chain expression, PICALM -rearranged leukemia/lymphoma, and SMARCB1 -deficient hematopoietic malignancies.
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Grier et al. (2026) studied this question.
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