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May 13, 2026Cochrane library

Pharmacological interventions for the treatment of obesity in children and adolescents

Chiara Gerardi Eleonora Allocati Gabriela Prutsky Francesco Maria Carrano Eugenia Romano Silvia De Giorgi Maria‐Inti Metzendorf Valeria Calcaterra Nicola Di Lorenzo Rita Banzi

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Key Points

To assess the benefits and harms of pharmacological interventions for treating obesity in children and adolescents.
Included 37 randomized controlled trials (RCTs) with 4218 participants focusing on individuals aged 0 to 19 years with obesity.
Evaluated pharmacological treatments administered for at least three months with a follow-up duration of six months or more.
Assessed outcomes like change in body mass index (BMI), weight change, adverse events, and quality of life.
Pharmacological interventions showed small reductions in BMI; evidence for this is very uncertain (mean difference pending).
Risk of discontinuation due to adverse events may increase with pharmacological treatments, though evidence remains very uncertain (RR 13.70, 95% CI 0.83 to 225.43).
Limited data available to conclude on adverse events and quality of life, particularly in children.

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Implication

Randomized trial assesses pharmacological interventions for obesity in children and adolescents, highlighting uncertain outcomes.

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Cite This Study

Gerardi et al. (2026) studied this question.

synapsesocial.com/papers/6a06b86ae7dec685947aae52 https://doi.org/10.1002/14651858.cd015986

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