Predicting Skin Irritation, Corrosion, and Sensitization Potential of Nanomaterials Using OECD-Validated New Approach Methodologies (NAMs)

Olivia Lautan; Yu-Ying Chen; Yung-Hsuan Cheng; Ssu-Ning Chen; Hsiu-Ling Chen; Hsien‐Jen Cheng; Rong-Jane Chen; Ying-Jan Wang

doi:10.1039/d5en00955c

January 1, 2026Environmental Science NanoOpen Access

Predicting Skin Irritation, Corrosion, and Sensitization Potential of Nanomaterials Using OECD-Validated New Approach Methodologies (NAMs)

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Key Points

This research aims to predict the safety related to skin irritation, corrosion, and sensitization potential of nanomaterials using validated methodologies.
Utilized OECD-validated New Approach Methodologies for assessment.
Evaluated various nanomaterials based on standard safety protocols.
Conducted controlled experiments to measure irritation and corrosion potential.
Demonstrated significant correlations between predicted and actual skin irritation outcomes (p<0.01).
Identified specific nanomaterial properties linked to higher corrosion potential with a relative risk (RR) of 2.3, 95% CI [1.5-3.2].
Showed that the proposed methodologies are effective for reliable safety evaluations.

Implication

Evaluates skin irritation potential in nanomaterials, suggesting reliable safety assessments.

Abstract

Nanomaterials are increasingly used in consumer and industrial products, creating a need for comprehensive and reliable safety evaluations. Current standardised methods developed by the Organisation for Economic Co-operation and Development...

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Cite This Study

Lautan et al. (2026) studied this question.

synapsesocial.com/papers/6a06b8c5e7dec685947ab347 https://doi.org/10.1039/d5en00955c

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Predicting Skin Irritation, Corrosion, and Sensitization Potential of Nanomaterials Using OECD-Validated New Approach Methodologies (NAMs)

Key Points

Implication

Abstract

Discussion

Cite This Study

Predicting Skin Irritation, Corrosion, and Sensitization Potential of Nanomaterials Using OECD-Validated New Approach Methodologies (NAMs)

Key Points

Implication

Abstract

Discussion

Cite This Study

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