New trichostatin analogs were identified in Streptomyces sp. DX6D14, indicating potential antibacterial and cytotoxic effects.
Six new trichostatin analogs, designated karstmycins I-M (1-6), together with eight known congeners (7-14), were obtained from Streptomyces sp. DX6D14 isolated from the soil of the karst cave. The structures of the new compounds were elucidated through spectroscopic analysis, including high-resolution electron spray ionization mass spectrometry (HRESIMS) and nuclear magnetic resonance (NMR), and electronic circular dichroism (ECD) calculations. All the isolates were evaluated for antibacterial and cytotoxic activities.
No takes yet. Share an insight, caveat, or question.
Yang et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: