Solvent recycling in solid-phase peptide synthesis (SPPS): combination of a swellable macroporous polystyrene (SMPS) resin and green binary solvents | Synapse
May 15, 2026Green Chemistry2 citationsOpen Access
Solvent recycling in solid-phase peptide synthesis (SPPS): combination of a swellable macroporous polystyrene (SMPS) resin and green binary solvents
To explore the use of green binary solvents in solvent recycling for solid-phase peptide synthesis (SPPS).
Combined swellable macroporous polystyrene resin with green binary solvents.
Analyzed the effectiveness of the approach compared to traditional solvents.
Green solvent alternatives demonstrated enhanced efficiency in SPPS.
Reduced reliance on hazardous solvents like DMF.
Abstract
Solid-phase peptide synthesis (SPPS) relies heavily on hazardous solvents, such as N , N ′-dimethylformamide (DMF), whose substitution by green solvents is proving more challenging than expected.