Assessment of retinal neurodegeneration in metabolic syndrome and its vascular determinants

PURPOSE: To evaluate retinal nerve fibre layer (RNFL) and ganglion cell complex (GCC) thickness in individuals with and without metabolic syndrome and examine associations with vascular risk factors. METHODS: In this prospective cross-sectional study, adults without ocular disease undergoing cardiovascular risk assessment were examined using spectral-domain optical coherence tomography (RTVue XR Avanti). RNFL and GCC thickness were measured. Associations between systemic factors and retinal layer thickness were analysed using linear regression with generalized estimating equations, stratified by metabolic syndrome status. Across all participants, smoking was associated with thinner GCC (β = -4.79 μm, p < 0.001). CONCLUSIONS: In this cardiovascular high-risk but ocular disease-free cohort, vascular factors, rather than metabolic syndrome itself, were associated with thinner RNFL and GCC. These findings suggest that vascular stress may contribute to early retinal neurodegeneration.