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This review aims to detail the mechanisms and implications of efferocytosis in various diseases.

May 15, 2026MedCommOpen Access

Efferocytosis: Signaling Pathways and New Therapeutic Strategies for Diseases

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This review aims to detail the mechanisms and implications of efferocytosis in various diseases.
Analysis of efferocytosis mechanisms and hallmarks of dysfunction across diseases.
Exploration of therapeutic strategies focused on enhancing or inhibiting efferocytosis.
Identified four hallmarks of defective efferocytosis: senescence-driven impairment, unresolved inflammation, loss of immune tolerance, and fibrotic repair.
Therapeutic interventions can enhance apoptotic clearance in chronic inflammatory conditions.
Inhibiting efferocytosis is essential for countering tumor-driven immunosuppression.

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Review outlines mechanisms of efferocytosis in disease and proposes targeted therapies with implications.

Wang et al. (2026) studied this question.

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