Randomized trial demonstrates a new method for creating fluorescent dyes, suggesting useful applications for biomedical imaging.
Fluorogenic heptamethine cyanines are highly desirable for biomedical imaging, yet there are limited strategies to develop them. Here, we report a polymethine reactivity-based approach in which a meso-carboxylate undergoes intramolecular nucleophilic attack at the γ-position, forming a cyclized structure that disrupts π-conjugation. These cyclizing Cy7 (c-Cy7) dyes have a solvent-dependent equilibrium between open (fluorescent) and closed (nonfluorescent) forms in polar and nonpolar solvents, respectively. Indolenine substitution can modulate cyclization equilibrium.
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Kumarasiri et al. (2026) studied this question.
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