Investigates lemborexant effects on sleep and cognition in dementia with Lewy bodies, suggesting good tolerability.
We investigated the effects of an orexin receptor antagonist on sleep profiles assessed by actigraphy, and cognitive function in patients with dementia with Lewy bodies (DLB). Thirteen probable DLB patients who were taking an orexin receptor antagonist for insomnia were recruited and underwent actigraphy before and after taking lemborexant. Cognitive function and severity of sleep disturbance were compared before and after taking lemborexant. No significant differences in sleep quality and cognitive function were observed in DLB patients between before and after taking lemborexant. These results suggest the tolerability of lemborexant in patients with DLB.
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Inagawa et al. (2026) studied this question.
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