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May 15, 2026Arabian Journal of ChemistryOpen Access

Cardiac troponin I biosensing on dipole-electrodes mediated interdigitated-zeolite transducer

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Authors

YDYu DongTLThangavel LakshmipriyaSGSubash C.B. Gopinath

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Overview

Randomized trial shows enhanced detection of cardiac troponin I in serum, suggesting improved CVD diagnostics.

Key Points

  • This study aims to develop a sensitive biosensor for detecting cardiac troponin I (cTnI) as a potential diagnostic tool for cardiovascular disease.
  • Developed a biosensor using silane-modified zeolite on interdigitated electrodes (IDE).
  • Attached glutaraldehyde premixed with anti-cTnI to the IDE to enhance antibody attachment.
  • Tested the sensor's ability to detect cTnI at concentrations ranging from 1 fM to 1 nM.
  • Detected cTnI at concentrations as low as 1 fM with a linear regression curve (1 fM to 1 nM) and R² = 0.9417.
  • Current increase observed with cTnI-spiked serum, confirming sensitivity.
  • Specificity confirmed through unchanged current responses with other proteins and nonimmune antibodies.

Cite This Study

Dong et al. (2026) studied this question.

synapsesocial.com/papers/6a06b8f8e7dec685947ab820https://doi.org/10.25259/ajc_680_2025
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