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May 15, 2026Central Nervous System Agents in Medicinal Chemistry

Translational Perspectives on Anti-Inflammatory Interventions for Neurodegenerative Disorders: Evidence from Gut-Brain Axis

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Authors

VSV.S. SaxenaDr. Bhim Rao Ambedkar UniversityVSVishwadeep SinghDr. Bhim Rao Ambedkar UniversitySSanskritiDr. Bhim Rao Ambedkar University

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Implication

Randomized trial demonstrates anti-inflammatory therapies targeting Gut-Brain Axis in neurodegenerative diseases, suggesting new treatment avenues.

Key Points

  • The aim is to explore the role of anti-inflammatory interventions in neurodegenerative disorders through the Gut-Brain Axis.
  • Summarizes preclinical and clinical data on anti-inflammatory therapies targeting the Gut-Brain Axis.
  • Evaluates microbiota-based treatments like probiotics and fecal microbiota transplantation.
  • Discusses dietary interventions including Mediterranean diets and polyphenol-rich foods.
  • Probiotics and fecal microbiota transplantation showed significant reductions in neuroinflammatory responses.
  • Mediterranean and polyphenol-rich diets positively modified gut microbiota composition and reduced pro-inflammatory signals.
  • Pharmacological substances like curcumin and resveratrol exhibited notable anti-neuroinflammatory effects.

Cite This Study

Saxena et al. (2026) studied this question.

synapsesocial.com/papers/6a06b914e7dec685947ab91chttps://doi.org/10.2174/0118715249430752260407050033
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