Longitudinal analysis investigates sleep regularity's impact on osteoporosis, suggesting it may help mitigate genetic risk.
Key Points
This research aims to explore the relationship between sleep regularity and osteoporosis risk, considering genetic susceptibility.
Longitudinal analysis using data from the UK Biobank with 87,231 participants monitored for osteoporosis from 2013 to 2023.
Analysis of sleep regularity parameters via accelerometer data, focusing on duration, onset time, wake-up time, and midpoint.
Subgroup and sensitivity analyses to further investigate associations and risk reductions.
2035 new osteoporosis cases recorded over the median follow-up of 8.6 years.
Higher osteoporosis risk in participants with greater variability in sleep regularity (HRs 1.17 to 1.21 for top quartile vs. bottom quartile).
Significant increase in osteoporosis risk for individuals with high polygenic risk scores when coupled with irregular sleep patterns (HRs 2.22 to 2.24).