What question did this study set out to answer?

Plant-Derived Phytochemicals and Polyherbal Formulations in AntimicrobialResistance: Mechanistic Evidence, Evidence Hierarchy, and TranslationalConstraints

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Narrative review synthesizes mechanistic and translational evidence on plant-based strategies to combat AMR, indicating new therapeutic avenues.

The aim is to explore the role of plant-derived phytochemicals and polyherbal formulations in addressing antimicrobial resistance.
Conducted a structured literature search across major scientific databases including PubMed, Scopus, and Web of Science.
Critically organized evidence according to experimental levels: in vitro, in vivo, and clinical data.
Reviewed the mechanisms of action for various phytochemicals against resistant bacterial strains.
Numerous plant-derived compounds exhibit antimicrobial effects, with mechanisms like membrane disruption and inhibition of biofilm formation.
Limited clinical trials and animal studies highlight the need for robust validation of efficacy and safety.
Challenges include variability in extract composition and insufficient pharmacokinetic data, affecting the translation to clinical use.

Ahirwar et al. (2026) studied this question.

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Narrative review synthesizes mechanistic and translational evidence on plant-based strategies to combat AMR, indicating new therapeutic avenues.