What question did this study set out to answer?

This study aims to evaluate the diagnostic performance and misclassification of preoperative MRI in rectal cancer staging.

May 15, 2026DiagnosticsOpen Access

Diagnostic Performance and Misclassification Patterns of Preoperative MRI in Rectal Cancer: A Real-World Study

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Real-world study shows moderate agreement of preoperative MRI with pathology in rectal cancer, suggesting implications for clinical practice.

This study aims to evaluate the diagnostic performance and misclassification of preoperative MRI in rectal cancer staging.
Conducted a retrospective study on 152 patients with pathologically confirmed rectal cancer.
Analyzed outcomes for patients treated with and without neoadjuvant therapy, using surgical pathology as reference.
Utilized Cohen’s kappa, sensitivity, and specificity calculations to assess MRI agreement with final pathology.
Overall agreement for T staging was 72.4%, and N staging was 73.0%, with moderate agreement (kappa = 0.452) for T and fair-to-moderate agreement (kappa = 0.349) for N.
Sensitivity for T-stage was 80.3%, while specificity was 67.0%; sensitivity for N-stage was 54.5%, with specificity at 80.6%.
NAT patients showed poorer initial MRI agreement (45.1%) compared to restaging MRI (72.0%) for T-stage.

Gómez et al. (2026) studied this question.

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Real-world study shows moderate agreement of preoperative MRI with pathology in rectal cancer, suggesting implications for clinical practice.