Neuroplasticity, Trauma, and Adaptive Brain Network Reorganization: A Systems Neuroscience Narrative Review.

This preprint presents a systems-neuroscience review examining how trauma, chronic stress, addiction, and recovery influence large-scale brain-network organization and neuroplastic adaptation. The manuscript integrates evidence from neuroscience, neuroimaging, behavioral neuroscience, and mental health research to explore dynamic interactions among the default mode network (DMN), salience network (SN), and executive control network (ECN). The review discusses network dysregulation, adaptive reorganization, emotional regulation, and implications for translational neuroscience and trauma-informed mental health frameworks.