What question did this study set out to answer?

This study aims to evaluate the prevalence of intestinal carbapenemase-producing organisms (CPO) and their associated clinical outcomes among hospitalized patients.

May 15, 2026BMC Infectious DiseasesOpen Access

Epidemiology and clinical outcomes of carbapenamase-producing organism (CPO) colonization: a tertiary care center experience in Saudi Arabia

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Authors

NANawaf M. AlzahraniKing Abdullah International Medical Research Center RAReem AbanamyKing Abdulaziz Medical City AAAbdulrahman AlsaedyKing Saud bin Abdulaziz University for Health Sciences

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Implication

Retrospective cohort study evaluates intestinal colonization and outcomes of carbapenemase-producing organisms in hospitalized adults, indicating urgent need for improved infection control.

Key Points

This study aims to evaluate the prevalence of intestinal carbapenemase-producing organisms (CPO) and their associated clinical outcomes among hospitalized patients.
Conducted a retrospective cohort study at King Abdulaziz Medical City in Riyadh, Saudi Arabia.
Screened 6405 hospitalized adult patients using rectal swabs and Cepheid Xpert® Carba-R test.
Analyzed associations between carbapenemase gene types and clinical outcomes using chi-square and t-tests.
Among screened patients, 778 carbapenemase-producing isolates were detected (12.1%).
30-day mortality rate was 24.6%, with no significant difference among carbapenemase types (p = 0.44).
Subsequent infection occurred in 29%, significantly associated with enzyme type (p = 0.001), highest among KPC (48.6%) and OXA-48 + NDM (38.1%).

Cite This Study

Alzahrani et al. (2026) studied this question.

synapsesocial.com/papers/6a06b998e7dec685947ac618 https://doi.org/10.1186/s12879-026-13570-6

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Implication

Retrospective cohort study evaluates intestinal colonization and outcomes of carbapenemase-producing organisms in hospitalized adults, indicating urgent need for improved infection control.

Epidemiology and clinical outcomes of carbapenamase-producing organism (CPO) colonization: a tertiary care center experience in Saudi Arabia

Discussion

Member takes

Implication

Key Points

Cite This Study

Epidemiology and clinical outcomes of carbapenamase-producing organism (CPO) colonization: a tertiary care center experience in Saudi Arabia

Discussion

Member takes

Implication

Key Points

Cite This Study

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