Site-Specific Post-Translational Modification Detection by Polar Charged Engineered MspA Nanopores

Shijun Lin; Yakun Yi; Yiheng Liu; Minglun Li; Fan Xia; Hai‐Chen Wu; Xiaoding Lou

doi:10.1039/d6sc01451h

January 1, 2026Chemical ScienceOpen Access

Site-Specific Post-Translational Modification Detection by Polar Charged Engineered MspA Nanopores

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Key Points

The aim is to effectively identify and analyze post-translational modifications in proteins using engineered nanopores.
Developed polar charged engineered MspA nanopores for detection
Applied techniques to discern low-abundance modified proteins
Utilized advanced analytical methods for resolving isobaric modifications.
Successfully detected various post-translational modifications with high accuracy
Achieved significant resolution of isobaric modifications
Demonstrated enhanced sensitivity compared to conventional methods.

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Implication

Detects post-translational modifications in proteins, suggesting new approaches for proteomic analysis.

Abstract

Deciphering the complex chemical code of post-translational modifications (PTMs) is fundamental to proteomics but remains challenging due to the low abundance of modified proteins and the difficulty in resolving isobaric...

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Cite This Study

Lin et al. (2026) studied this question.

synapsesocial.com/papers/6a06b998e7dec685947ac62d https://doi.org/10.1039/d6sc01451h

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Site-Specific Post-Translational Modification Detection by Polar Charged Engineered MspA Nanopores

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Site-Specific Post-Translational Modification Detection by Polar Charged Engineered MspA Nanopores

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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