Organo‐Catalytic Regioselective Synthesis of Pyrroloacridines From Unsymmetrical Cyclic 1,3‐Diketone in Eco‐Benign Solvent

In this study, an amalgamation between multicomponent (MCR) strategy and organocatalysis for the synthesis of pyrroloacridine derivatives starting from 4,4‐dimethylcyclohexane‐1,3‐dione, amines, and isatin has been reported in eco‐friendly solvent EtOH. Since, here the cyclic 1,3‐diketone being used is structurally unsymmetrical; there is possibility of formation of two different products. However, the reaction shows very high regioselectivity and produces one product almost exclusively. Moreover, use of adipic acid as an organo‐catalyst, EtOH as eco‐benign solvent and moderate reaction temperature align this reaction with the postulates of green chemistry. The reaction shows high reproducibility and broad substrate tolerance. The synthesized pyrroloacridine molecules have great application in the field of medicinal chemistry and material sciences. All these features make this present work worthy to disclose to broad scientific community.