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Demonstrates improved solubility of luliconazole using mixed hydrotropy in drug formulation, suggesting a practical approach for pharmaceutical applications.
One of the common challenges in pharmaceutical research is the low solubility of many drug molecules, which directly affects their formulation as well as their therapeutic effectiveness. When a drug does not dissolve properly in water, its absorption and overall performance can be reduced. Luliconazole is a widely used antifungal drug for the treatment of skin infections, but it has poor aqueous solubility, making it difficult to develop an efficient and stable formulation. To address this issue, different solubility enhancement techniques are used in pharmaceutical science. Among these, mixed hydrotropy is considered a simple and effective method. In this approach, two or more hydrotropic agents are used together to increase the solubility of a poorly water-soluble drug, without relying on organic solvents. This makes the method safer, cost-effective, and more suitable for pharmaceutical applications. In the present study, sodium benzoate and sodium citrate were selected as hydrotropic agents. These agents are commonly used and are known for their solubilizing properties. The main objective of this work was to study how their combination can improve the solubility of Luliconazole in water. This study aims to provide a practical and economical solution for enhancing drug solubility in pharmaceutical formulations.
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Chaudhari et al. (2026) studied this question.
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