What question did this study set out to answer?

The aim is to highlight a rare case of non-Candida fungal cholecystitis and its management in a patient post-hematopoietic cell transplant.

May 15, 2026Open Access

Non-Candida fungal cholecystitis - an uncommon occurrence even in the right host

Key Points

The aim is to highlight a rare case of non-Candida fungal cholecystitis and its management in a patient post-hematopoietic cell transplant.
Presented a case of Lomentospora prolificans causing acute cholecystitis
Treatment involved temporary cholecystostomy and fosmanogepix administration
The patient underwent cholecystectomy at 6 weeks post-HCT.
Patient achieved resolution of infection post-treatment with fosmanogepix
Successful management of cholecystitis following cholecystectomy
Literature review indicates rarity of non-Candida fungal cholecystitis cases.

Abstract

Abstract Invasive fungal infections (IFI) are a significant cause of morbidity and mortality in hematologic malignancy patients and hematopoietic cell transplant (HCT) recipients. Mold cholecystitis has rarely been described. We present a case of disseminated Lomentospora prolificans , that had recrudescence of symptoms with acute cholecystitis. Treatment included a temporary cholecystostomy and administration of the novel antifungal fosmanogepix. At 6 weeks post-HCT, the patient underwent cholecystectomy and completed a course of fosmanogepix, leading to resolution of her infection. Here we review the published literature on non- Candida fungal cholecystitis, underlying risk factors and treatment.

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Cite This Study

Dumais et al. (Thu,) studied this question.

synapsesocial.com/papers/6a06b9e2e7dec685947ac8fb https://doi.org/https://doi.org/10.1007/s10096-026-05541-1

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