Key result
Endothelial cell-derived IGFBPs preferentially localized in connective tissue elements of the rat myocardium (ratio >=10:1), whereas amniotic fluid IGFBP-1 predominantly localized in cardiac muscle.
Population
Isolated beating rat hearts and intact anesthetized rats
Design
Preclinical
Follow-up
1 and 5 minutes
Authors
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Differential IGFBP localization patterns in rat myocardium are hypothesis-generating; leaves open relevance to human cardiac remodeling.
Endothelial cell-derived IGFBPs and amniotic fluid IGFBP-1 can cross capillary boundaries in the rat heart but exhibit distinct subendothelial tissue distributions.
Bar et al. (1990) studied this question. 125I-ECBP and 125I-IGFBP-1 perfusion vs. 125I-IGF-I was evaluated on Transcapillary permeability and subendothelial distribution (connective tissue:muscle ratio). Endothelial cell-derived IGFBPs preferentially localized in connective tissue elements of the rat myocardium (ratio >=10:1), whereas amniotic fluid IGFBP-1 predominantly localized in cardiac muscle.
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