Why the study?
Does NSILA-S have similar effects to insulin on glucose uptake, lactate production, and efflux of 3-0-methyl glucose in the isolated perfused rat heart?
Population
Isolated perfused rat heart
Comparison
Nonsuppressible insulin-like activity extracted… vs Insulin (200 muU per ml perfusion medium)
Design
Preclinical
Authors
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Hypothesis-generating for NSILA-S as insulin mimetic in rat myocardium; leaves open human translation.
Does NSILA-S have similar effects to insulin on glucose uptake, lactate production, and efflux of 3-0-methyl glucose in the isolated perfused rat heart?
NSILA-S exerts metabolic effects on the isolated rat heart that are nearly identical to those of insulin, including stimulation of glucose uptake and lactate production.
Meuli et al. (1975) studied this question.
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