Why the study?
Does NSILA have similar metabolic actions and clearance rates as crystalline insulin in the isolated perfused rat heart?
Population
Isolated perfused rat heart
Comparison
Porcine nonsuppressible insulin-like activity vs Crystalline insulin
Design
Preclinical
Follow-up
60 minutes
Authors
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NSILA may exert prolonged insulin-like myocardial effects in rats; this Level 5 evidence leaves open any physiologic or clinical role in humans.
Does NSILA have similar metabolic actions and clearance rates as crystalline insulin in the isolated perfused rat heart?
NSILA exerts insulin-like metabolic effects on the myocardium without being cleared, suggesting a potential long-acting physiologic role.
Solomon et al. (1967) studied this question.
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