Key result
Insulin activated a novel, voltage-dependent, nonselective cation current in guinea pig ventricular myocytes via a phospholipase C-dependent, protein kinase C-independent pathway.
Population
Guinea pig isolated ventricular myocytes
Comparison
Insulin and various pharmacological agents… vs Baseline/control conditions under voltage clamp
Design
Preclinical
Authors
Loading...
Hypothesis-generating for insulin effects on cardiac ion channels; leaves open relevance to human electrophysiology or disease.
Insulin activates a novel voltage-dependent nonselective cation current in guinea pig ventricular myocytes via a phospholipase C-dependent pathway.
Zhang et al. (2003) studied Guinea pig isolated ventricular myocytes. Insulin was evaluated on Activation of an outwardly rectifying current (Iinsulin). Insulin activated a novel, voltage-dependent, nonselective cation current in guinea pig ventricular myocytes via a phospholipase C-dependent, protein kinase C-independent pathway.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: