Key result
Insulin stimulates the L-type calcium current in isolated rat ventricular myocytes in a dose-dependent and reversible manner, with a maximum stimulation of 86 +/- 11% over basal levels at 1 microM.
Why the study?
Does insulin stimulate the L-type calcium current in isolated rat ventricular myocytes?
Population
Isolated rat ventricular myocytes
Comparison
Insulin (dose-dependent, up to 1 microM) vs Basal state (no insulin)
Design
Preclinical
Authors
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Hypothesis-generating for insulin effects on cardiac calcium currents; leaves open translation to human ventricular function.
Does insulin stimulate the L-type calcium current in isolated rat ventricular myocytes?
Insulin stimulates the L-type calcium current in isolated rat ventricular myocytes in a dose-dependent and reversible manner, likely mediated by insulin receptors and cAMP-dependent protein kinase.
F Aulbach (1999) studied Isolated rat ventricular myocytes. Insulin vs. Basal state / Isoproterenol was evaluated on L-type calcium current (ICa,L) stimulation. Insulin stimulates the L-type calcium current in isolated rat ventricular myocytes in a dose-dependent and reversible manner, with a maximum stimulation of 86 +/- 11% over basal levels at 1 microM.
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