Why the study?
Does insulin exert positive inotropic effects and what are its signal transduction mechanisms in failing human myocardium?
Population
Isolated trabeculae from end-stage failing hearts of 61 patients undergoing heart transplantation.
Design
Preclinical
Authors
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Provides mechanistic basis for insulin in failing myocardium; leaves open clinical translation pending human studies.
Does insulin exert positive inotropic effects and what are its signal transduction mechanisms in failing human myocardium?
Insulin exerts Ca2+-dependent and -independent positive inotropic effects through a PI-3-kinase-dependent pathway in failing human myocardium, providing a mechanistic basis for the clinical effects of insulin-glucose-potassium infusions.
Lewinski et al. (2005) studied this question.
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