Key result
Insulin significantly reduced the contraction force of right ventricular papillary muscles in both healthy control rats and rats with chronic diabetes.
Why the study?
Does insulin reduce cardiac contraction force in papillary muscles from control and diabetic rats?
Population
Right ventricular papillary muscles from control rats and rats with chronic diabetes
Comparison
Insulin (80 IU/l) vs Baseline/control conditions (without insulin)
Design
Preclinical
Authors
Loading...
Should not alter insulin use in diabetes; hypothesis-generating for negative inotropy in ventricular myocardium.
Does insulin reduce cardiac contraction force in papillary muscles from control and diabetic rats?
Absolute Event Rate: 14% vs 23%
p-value: p=<0.05
Insulin exerts a negative inotropic effect in both control and diabetic rat myocardium, likely related to processes of SR Ca2+ release triggering via L-type Ca2+ channels.
ŠVÍGLEROVÁ et al. (2005) studied Diabetes mellitus (n=42). Insulin vs. Baseline (insulin-free solution) was evaluated on Contraction force at 1 Hz stimulation in diabetic rats (arbitrary units) (p=<0.05). Insulin significantly reduced the contraction force of right ventricular papillary muscles in both healthy control rats and rats with chronic diabetes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: