Key result
Insulin-resistant ob/ob mouse cardiomyocytes exhibited decreased DAG-mediated non-selective cation currents, lower TRPC3 expression, and defective insulin-mediated TRPC3 trafficking compared to WT.
Population
Ventricular cardiomyocytes isolated from adult wild-type (WT) and insulin-resistant, obese ob/ob mice
Comparison
Insulin pretreatment and application of membrane… vs Wild-type cardiomyocytes vs insulin-resistant…
Design
Preclinical
Authors
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Impaired TRPC3 function in insulin-resistant cardiomyocytes may contribute to diabetic cardiomyopathy; hypothesis-generating for targeted therapies.
Insulin resistance in cardiomyocytes impairs DAG-mediated non-selective cation currents due to reduced TRPC3 expression and defective insulin-mediated trafficking.
Fauconnier et al. (2006) studied Insulin resistance. Insulin and OAG (DAG analogue) vs. Wild-type (WT) cardiomyocytes was evaluated on Non-selective cation currents (NSCC) and TRPC3 channel expression/translocation. Insulin-resistant ob/ob mouse cardiomyocytes exhibited decreased DAG-mediated non-selective cation currents, lower TRPC3 expression, and defective insulin-mediated TRPC3 trafficking compared to WT.
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