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June 1, 1989AJP Cell Physiology

Isoproterenol, DBcAMP, and forskolin inhibit cardiac sodium current

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Population

Guinea pig ventricular myocytes

Comparison

Isoproterenol, dibutyryl adenosine 3',5'-cyclic… vs Control (baseline peak sodium current)

Design

Preclinical

Authors

OKOno KTKTatsuto KiyosueMAMakoto Arita

Discussion

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Overview

Hypothesis-generating for beta-adrenergic modulation of cardiac excitability; leaves open relevance to human conduction or arrhythmias.

Structured PICO

P
Population
Guinea pig ventricular myocytes
I
Intervention
Isoproterenol (1 microM), dibutyryl adenosine 3',5'-cyclic monophosphate (DBcAMP) (1-5 mM), and forskolin (3 microM)
C
Comparator
Control (baseline peak sodium current)
O
Outcome
Peak sodium current (INa)surrogate

Isoproterenol, DBcAMP, and forskolin inhibit cardiac sodium current, likely via increased intracellular cAMP and subsequent channel phosphorylation.

Cite This Study

K et al. (1989) studied this question.

synapsesocial.com/papers/6a83fc67addadcf8413c21e4https://doi.org/10.1152/ajpcell.1989.256.6.c1131
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Early outward current in rat single ventricular cells.1984 · 323 citations
  2. 2Properties of Two Inward Membrane Currents in the Heart1979 · 407 citations
  3. 3Adrenergic modulation of the transient outward current in isolated canine Purkinje cells.1988 · 89 citations
  4. 4A quantitative description of membrane current and its application to conduction and excitation in nerve1952 · 23,521 citations