Why the study?
Does insulin improve glucose uptake in isolated working rat hearts during and after low-flow ischemia?
Population
Working hearts from fasted rats
Comparison
Insulin added before, during, or after a 45-min… vs Control conditions (perfusion without insulin)
Design
Preclinical
Follow-up
15 min pre-ischemia, 45 min ischemia, 30 min post-ischemia
Authors
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Caution against clinical use from rat data alone; leaves open translation of insulin-stimulated uptake to human ischemia-reperfusion.
Does insulin improve glucose uptake in isolated working rat hearts during and after low-flow ischemia?
Insulin stimulates glucose uptake in normal and ischemic hearts of fasted rats, suggesting separate intracellular signaling pathways for hexose transport sensitive to metabolic requirements and insulin.
Chen et al. (1997) studied this question.
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