Why the study?
Does high glucose perfusion improve functional recovery and reduce ischemic injury in isolated rat hearts subjected to low-flow ischemia?
Population
Isolated rat hearts paced at 300 beats/min
Comparison
High glucose perfusion in buffer containing 0.4… vs Normal glucose perfusion under the same conditions
Design
Preclinical
Follow-up
50 min of low-flow ischemia and 60 min of reperfusion
Authors
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High-glucose effects in isolated hearts warrant no clinical change; leaves open GLUT-4 translocation as a cardioprotective target for future study.
Does high glucose perfusion improve functional recovery and reduce ischemic injury in isolated rat hearts subjected to low-flow ischemia?
High glucose protects ischemic myocardium by increasing sarcolemmal content of insulin-sensitive GLUT-4, suggesting a potential target for cardioprotection.
Ramasamy et al. (2001) studied this question.
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