Key result
Adding D-dimer to Caprini scores improves preoperative VTE prediction in elderly hip fractures to ~0.68 AUC.
Why the study?
Does integrating D-dimer and injury-to-admission time into the Caprini model improve preoperative VTE risk assessment in elderly hip fracture patients?
Observational
No
Does integrating D-dimer and injury-to-admission time into the Caprini model improve preoperative VTE risk assessment in elderly hip fracture patients?
Absolute Event Rate: 0.681% vs 0.552%
p-value: p=<.001
Integrating D-dimer and injury-to-admission time into the Caprini model improves preoperative VTE risk stratification in elderly hip fracture patients.
Should not yet alter preoperative VTE assessment in hip fracture; extends Caprini utility but requires prospective validation.
< .001). Combining the Caprini score with the D-dimer level provided a more accurate prediction (AUC: 0.681), significantly outperforming the Caprini score alone (AUC: 0.552). When the sensitivity exceeded 95%, the D-dimer threshold model across the three Caprini risk levels outperformed the Caprini risk levels combined with the D-dimer level (AUC: 0.592 vs 0.571) and demonstrated a significant advantage at 100% sensitivity.ConclusionsReclassifying the Caprini score into three risk levels may improve preoperative VTE stratification in elderly hip fracture patients. Integrating the injury-to-admission time and D-dimer level into the Caprini model was associated with improved predictive performance. Standardizing the timing of D-dimer sampling may reduce timing-related variability in VTE assessment. External multicentre validation is warranted.
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Guo et al. (2025) conducted an observational in Preoperative Venous Thromboembolism in Elderly Hip Fracture. Refined Caprini model integrating D-dimer and injury-to-admission time vs. Caprini score alone was evaluated on Preoperative VTE prediction accuracy (AUC) (p=<.001). Combining the Caprini score with D-dimer level provided a more accurate prediction of preoperative VTE in elderly hip fracture patients than the Caprini score alone (AUC 0.681 vs 0.552, P<.001).
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