Key result
PHD1 knockout reduces glucose intolerance in mice fed a high-fat diet.
Why the study?
Does PHD1 knockout improve glucose intolerance in diet-induced obesity mice?
Does PHD1 knockout improve glucose intolerance in diet-induced obesity mice?
PHD1 knockout in mice attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia, suggesting a protective metabolic phenotype for cardiovascular disease.
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PHD1 inhibition may protect against diet-induced metabolic dysfunction in mice; leaves open human translation and clinical relevance.
Marsch et al. (2016) studied Diet-induced obesity. PHD1 knockout vs. Wild-type littermate controls was evaluated on Glucose intolerance. PHD1 knockout mice fed a high-fat diet for 14 weeks were less glucose intolerant compared with wild-type littermate controls, displaying a protective metabolic phenotype.
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