Despite normal LVEF, patients with OSAS have decreased function in three LV wall layers, and those with severe OSAS experience earlier myocardial systolic dyssynchrony compared with controls.
Case-Control
Does obstructive sleep apnoea syndrome cause subclinical left ventricular myocardial dysfunction and dyssynchrony in patients with normal LVEF?
Speckle-tracking echocardiography reveals subclinical multi-layer left ventricular dysfunction and systolic dyssynchrony in patients with severe OSAS despite preserved LVEF.
p-value: p=0.005
OBJECTIVE: To evaluate the subclinical left ventricular (LV) myocardial dysfunction by myocardial layer-specific and dyssynchorony analysis in patients with obstructive sleep apnoea syndrome (OSAS) with normal left ventricular ejection fraction (LVEF) and without any confounding disease that can cause myocardial dysfunction. METHODS: = 18) OSAS and 20 controls underwent both standard conventional echocardiography assessment, myocardial layer-specific and dyssynchorony analysis. Changes in the levels of norepinephrine (NE) were analysed. RESULTS: = .005) from the middle segment, and all segments from apical segments. PSD and TTP in the moderate OSAS group had no significant differences when compared with control group. CONCLUSIONS: Despite normal LVEF, three layers (endocardial, myocardial and epicardia) of LV wall are decreased in OSOA patients, patients in the severe OSAS group suffer from myocardial systolic dyssynchrony earlier compared with controls.
Huang et al. (Tue,) conducted a case-control in Obstructive sleep apnoea syndrome (OSAS). Speckle-tracking echocardiography vs. Controls was evaluated on Subclinical left ventricular myocardial dysfunction (p=0.005). Despite normal LVEF, patients with OSAS have decreased function in three LV wall layers, and those with severe OSAS experience earlier myocardial systolic dyssynchrony compared with controls.