Key result
High SDOH scores linked to ~113% greater CVD mortality, partially mediated by behavioral and clinical risks.
Why the study?
Social determinants of health contribute to increased CVD mortality, but the mediating effects of behavioral and clinical risk factors in this association required investigation.
Does unfavorable social determinants of health increase cardiovascular disease mortality in adults aged ≥20 years?
Cohort (n=50,808)
Does unfavorable social determinants of health increase cardiovascular disease mortality in adults aged ≥20 years?
Effect estimate: HR 2.13 (95% CI 1.91-2.37)
Behavioral and clinical risk factors mediate nearly one-third of the excess cardiovascular mortality risk associated with unfavorable social determinants of health.
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Excess CVD mortality with unfavorable SDOH persists after behavioral adjustment; extends mediation data but leaves causal effects open.
He et al. (2025) conducted a cohort in Cardiovascular Disease Mortality (n=50,808). Unfavorable social determinants of health (composite SDOH score ≥ median) vs. Favorable social determinants of health (composite SDOH score < median) was evaluated on Cardiovascular disease mortality (HR 2.13, 95% CI 1.91-2.37). A composite social determinants of health score at or above the median was associated with a 2.13-fold increased risk of cardiovascular disease mortality, of which 30.8% was mediated by behavioral and clinical risk factors.
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