Key result
High cardiovascular health is linked to lower all-cause mortality in prediabetic adults.
Why the study?
Patients with prediabetes face increased risk of cardiovascular disease, and quantifying cardiovascular health using the American Heart Association Life's Essential 8 score may help confirm whether health interventions reduce mortality risk in this population.
Does high cardiovascular health status (quantified by LE8 score) reduce all-cause mortality in prediabetic patients?
Cohort (n=5,344)
Does high cardiovascular health status (quantified by LE8 score) reduce all-cause mortality in prediabetic patients?
High cardiovascular health status, particularly improved health behaviors, is associated with reduced all-cause mortality in prediabetic adults.
BACKGROUND: Patients with prediabetes are at increased risk of developing cardiovascular disease. The Life's Essential 8 (LE8) score, updated by the American Heart Association in 2022, is a tool used to quantify cardiovascular health (CVH). Quantifying healthy living status on the basis of the uniform standard LE8 will be useful for confirming whether health interventions can reduce the risk of death in prediabetic patients. AIM: To investigate the associations between all-cause mortality risk and CVH status (as quantified by the LE8 score) in prediabetic patients. METHODS: This study included 5344 participants with prediabetes (age: 52.9 ± 15.8 years; 51.6% men). The LE8 score includes four health indicators and four health behaviors. Cox proportional hazard ratios were calculated for all-cause mortality in the high CVH (LE8 ≥ 80), low CVH (LE8 ≤ 50), and moderate CVH (LE8 50-79) subgroups, and restricted cubic spline analyses were performed. Separate analyses of the associations of all-cause mortality risk with each LE8 component and CVH health behaviors and indicators were also performed. RESULTS: -nonlinear = 0.7989). Improved CVH health behaviors had a more significant protective effect on patients with prediabetes than did the improvement in CVH health indicators. CONCLUSION: High CVH status (as quantified by the LE8 score) is significantly associated with reduced mortality risk in prediabetic adults in the United States.
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Chen et al. (2025) conducted a cohort in Prediabetes (n=5,344). High cardiovascular health status (Life's Essential 8 score ≥ 80) vs. Low CVH (LE8 ≤ 50) and moderate CVH (LE8 50-79) was evaluated on All-cause mortality. High cardiovascular health status (LE8 score ≥ 80) was significantly associated with reduced all-cause mortality risk in prediabetic adults.
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