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, as evidenced by a slower decrease in the absorbance at 404 nm compared to PS2.M and more sustained catalysis. NMR spectroscopy indicates that hemin promotes ligand-induced structure formation in the Hem1-2T aptamer and forms a specific complex, whereas hemin interacts with the PS2.M G-quadruplex in a way leading to the disappearance of NMR peaks. Overall, the Hem1-2T-hemin complex is a better and more stable HRP mimic, supporting its potential applications in bioanalysis and biocatalysis.
Rodríguez-Almazán et al. (Tue,) studied this question.