Key result
High genetic risk is linked to AF and CV complications, although weaker in HCM.
Why the study?
Clinical and genetic predispositions predict AF, but their role in patients with hypertrophic cardiomyopathy remains unclear.
Do clinical and genetic risk factors predict the development of atrial fibrillation in patients with and without hypertrophic cardiomyopathy?
Cohort
Do clinical and genetic risk factors predict the development of atrial fibrillation in patients with and without hypertrophic cardiomyopathy?
Genetic predisposition is associated with the development of AF and cardiovascular complications in people with and without HCM, though the association is weaker in the HCM group.
Answers are grounded in this paper and cite their sources.
Supports genetic risk stratification for AF in HCM; extends non-HCM associations but leaves open prospective validation.
BACKGROUND: Clinical and genetic predispositions are significant in predicting atrial fibrillation (AF); however, their role in patients with hypertrophic cardiomyopathy (HCM) remains unclear. This study aims to elucidate the impact of clinical and genetic risk factors on the development of AF in patients with and without HCM. METHODS AND RESULTS: =0.005 for interaction). A high genetic risk was significantly associated with the risk of cardiovascular complications in both groups. CONCLUSIONS: Genetic predisposition is associated with the development of AF and cardiovascular complications in people with and without HCM; this association was weaker in the HCM group.
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Lee et al. (2025) conducted a cohort in Hypertrophic cardiomyopathy. High genetic risk vs. Low genetic risk was evaluated on Development of atrial fibrillation and cardiovascular complications (p==0.005 for interaction). High genetic risk was associated with atrial fibrillation and cardiovascular complications in patients with and without hypertrophic cardiomyopathy, though weaker in the HCM group (P=0.005).
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