What question did this study set out to answer?

To identify the clinical impact, risk factors, and prognostic significance of atrial fibrillation in a large cohort of patients with hypertrophic cardiomyopathy.

February 20, 2017Hellenic Journal of CardiologyOpen Access

Atrial fibrillation in hypertrophic cardiomyopathy: A turning point towards increased morbidity and mortality

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Why the study?

Does atrial fibrillation increase the risk of mortality and stroke in patients with hypertrophic cardiomyopathy?

Population

509 patients with an established diagnosis of hypertrophic cardiomyopathy (HCM)

Comparison

Atrial fibrillation (AF) vs No atrial fibrillation

Design

Cohort

Authors

TZThomas ZegkosHeart Failure & Transplant GEGeorgios EfthimiadisGeneral Cardiology DPDespοina ParcharidouLeiden University Medical Center

Discussion

Member takes

Implication

AF warrants closer surveillance in HCM; extends risk stratification data but leaves causal questions open for trials.

Key Points

To identify the clinical impact, risk factors, and prognostic significance of atrial fibrillation in a large cohort of patients with hypertrophic cardiomyopathy.
Evaluated clinical and echocardiographic correlates, stroke risk factors, and prognostic outcomes in 509 patients with confirmed hypertrophic cardiomyopathy.
Atrial fibrillation occurred in 23.4% of patients (119/509), and left atrial diameter independently predicted arrhythmia onset (OR: 2.2, 95% CI: 1.6–3.3) and thromboembolic stroke (OR: 1.6, 95% CI: 1.01–2.40).
Atrial fibrillation was an independent risk factor for overall mortality (HR: 3.4, 95% CI: 1.7–6.5), HCM-related mortality (HR: 3.9, 95% CI: 1.8–8.2), and heart failure-related mortality (HR: 6.0, 95% CI: 2.0–17.9), but did not affect sudden death risk.

Structured PICO

Does atrial fibrillation increase the risk of mortality and stroke in patients with hypertrophic cardiomyopathy?

Population

509 patients with an established diagnosis of hypertrophic cardiomyopathy (HCM)

Intervention

Atrial fibrillation (AF)

Comparator

No atrial fibrillation

Outcome

Overall mortality, HCM-related mortality, heart failure-related mortality, and sudden deathhard clinical

In patients with hypertrophic cardiomyopathy, atrial fibrillation is associated with significantly increased risks of overall, HCM-related, and heart failure-related mortality, while left atrial size predicts both AF and stroke.

Cite This Study

Zegkos et al. (2017) studied this question.

synapsesocial.com/papers/6a7d8459e5d85d18548c8db3 https://doi.org/10.1016/j.hjc.2017.01.027

Topics

Atrial fibrillation Persistent AF management Echocardiography Cardiac MRI Hypertrophic cardiomyopathy

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Atrial fibrillation in hypertrophic cardiomyopathy: A turning point towards increased morbidity and mortality

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Atrial fibrillation in hypertrophic cardiomyopathy: A turning point towards increased morbidity and mortality

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider