Severe Bone Microarchitecture Impairment in Women With Pregnancy and Lactation-Associated Osteoporosis

CONTEXT: Pregnancy- and lactation-associated osteoporosis (PLO) is a rare condition characterized by fragility fractures, mostly vertebral, during the third trimester of pregnancy or the early postpartum period. OBJECTIVE: The aim of this study was to evaluate bone microarchitecture in women with PLO to better understand the pathophysiology of this disease. METHODS: In this retrospective study, we included women with PLO referred to our bone center between November 2007 and July 2012. We assessed bone mineral density (BMD) by dual-energy x-ray absorptiometry, bone turnover markers, and bone microarchitecture by high-resolution peripheral quantitative computed tomography. Results were compared with a control group of healthy lactating women. RESULTS: = .01, respectively). Cortical parameters were also deteriorated but to a lesser extent. CONCLUSION: In comparison with healthy lactating women, patients with PLO presented severe deterioration of bone trabecular and cortical microarchitecture. This significant compromise may explain the occurrence of multiple fractures in these otherwise healthy young women. Further prospective studies are needed to determine whether bone microarchitecture might be able to be restored in the future.