Engineering the Bioactivity of Flame-Made Ceria and Ceria/Bioglass Hybrid Nanoparticles

ratio which needs to be controlled to compare different nanoceria systems. In this work, we demonstrate that liquid-feed flame spray pyrolysis offers excellent control over the oxidation state in a one-step synthesis of nanoceria. This control allows a comprehensive comparison of different types of ceria nanoparticles. We connect physicochemical characteristics to biomedically relevant properties such as superoxide dismutase and catalase mimicry, human monocyte and macrophage protection, and antimicrobial activity. Furthermore, we demonstrate how the synthesis method also allows tailoring the properties of ceria/bioglass hybrid nanoparticles, thus creating nanoparticles with manifold biomedical prospects.