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Rapid and effective hemostasis is a necessary prerequisite for the management and repair of wounds. Natural polysaccharide-based hydrogel dressings are attractive in hemostasis and wound repair. In this review, the physiological mechanism of hemostasis and the design rationale of polysaccharide hydrogels from a physiochemical perspective is summarized. Then, the recent progress of multifunctional hemostatic polysaccharide hydrogel wound dressings that are characterized by high antibacterial activity, a high degree of tissue adhesion, good biocompatibility, and tunable swelling and degradation properties is reported. Finally, the personal perspectives on the current challenges and future developments of polysaccharide-derived hemostatic hydrogels are proposed. • An overview of the use of natural polysaccharide-based hydrogels for hemostasis and wound healing is provided. • The mechanisms of wound healing and hemostasis are summarized. • Design strategies of polysaccharide-based hydrogels using various crosslinking approaches are highlighted. • Advances in the development of hydrogels derived from diverse natural polysaccharides with tailored biological properties.
Wang et al. (Sat,) studied this question.
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