Key result
Use of loop diuretics in patients with older onset diabetes was associated with an increased risk of death (OR 1.8; 95% CI 1.4-2.2).
Cohort
Effect estimate: OR 1.8 (95% CI 1.4-2.2)
Caution advised against causal inference from loop diuretic–mortality link in older-onset diabetes; leaves open confounding and need for prospective trials.
Mortality follow-up for a cohort defined in 1980 with diabetes diagnosed at 30 years of age or older has been completed through 1988. History of medication use was obtained during the initial evaluation. There were 605 (44.2%) confirmed deaths; heart disease was the underlying cause in 49.9% of the deaths. Use of loop diuretics was associated with an odds ratio of death of 1.8 (95% CI = 1.4, 2.2). Although a causal relationship cannot be inferred, it is reasonable to suggest that blood chemistries be monitored regularly in persons on these drugs since electrolyte imbalance may be related to death.
No takes yet. Share an insight, caveat, or question.
Klein et al. (1992) conducted a cohort in Older onset diabetes. Loop diuretics was evaluated on Mortality (OR 1.8, 95% CI 1.4-2.2). Use of loop diuretics in patients with older onset diabetes was associated with an increased risk of death (OR 1.8; 95% CI 1.4-2.2).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: