Total physical activity was inversely associated with biomarkers of endothelial dysfunction (standardised β -0.11), with consistently stronger associations in individuals with prediabetes and type 2 diabetes.
Cross-Sectional (n=2,363)
No
Are physical activity and sedentary behaviour associated with biomarkers of endothelial dysfunction and low-grade inflammation in individuals with and without (pre)diabetes?
Physical activity and sedentary behavior are associated with biomarkers of endothelial dysfunction and low-grade inflammation, with the impact on endothelial dysfunction being more pronounced in individuals with prediabetes and type 2 diabetes.
Effect estimate: Standardised β -0.11 (95% CI -0.15, -0.07)
p-value: p=<0.001
AIMS/HYPOTHESIS: Biomarkers of endothelial dysfunction and low-grade inflammation are important in the pathogenesis of CVD and can potentially be modified by physical activity and sedentary behaviour. Effects of physical activity on biomarkers of endothelial dysfunction may be especially prominent in type 2 diabetes. METHODS: In the population-based Maastricht Study (n = 2363, 51.5% male, 28.3% type 2 diabetes, 15.1% prediabetes defined as impaired glucose tolerance and impaired fasting glucose), we determined biomarkers of endothelial dysfunction and low-grade inflammation, and combined z scores were calculated. Physical activity and sedentary behaviour were measured by activPAL. Linear regression analyses were used with adjustment for demographic, lifestyle and cardiovascular risk factors. RESULTS: The association between total, light, moderate-to-vigorous and vigorous intensity physical activity and sedentary time on the one hand and biomarkers of endothelial dysfunction on the other were generally significant and were consistently stronger in prediabetes and type 2 diabetes as compared with normal glucose metabolism status (p for interaction 0.05). CONCLUSIONS/INTERPRETATION: Physical activity and sedentary behaviour are associated with biomarkers of endothelial dysfunction and low-grade inflammation. For biomarkers of endothelial dysfunction, associations between physical activity and sedentary behaviour were consistently stronger in (pre)diabetes than in normal glucose metabolism. Whether increasing physical activity or decreasing sedentary time can positively influence biomarkers of endothelial dysfunction in individuals with prediabetes and type 2 diabetes requires further study.
Vandercappellen et al. (Fri,) conducted a cross-sectional in Type 2 diabetes, prediabetes, and normal glucose metabolism (n=2,363). Physical activity and sedentary behaviour vs. Lower physical activity / higher sedentary time was evaluated on Biomarkers of endothelial dysfunction z-score (Standardised β -0.11, 95% CI -0.15, -0.07, p=<0.001). Total physical activity was inversely associated with biomarkers of endothelial dysfunction (standardised β -0.11), with consistently stronger associations in individuals with prediabetes and type 2 diabetes.