Endothelial extracellular vesicles act as intercellular communicators that exert both harmful and beneficial effects on vascular function, serving as potential diagnostic and therapeutic targets in diabetic vascular complications.
Endothelial extracellular vesicles represent promising diagnostic markers and therapeutic targets for understanding and managing diabetic vascular complications.
Diabetic vascular complications attract increased attention due to their high morbidity, mortality and disability rate. Comprehensive and in-depth exploration of the etiology and pathogenesis of diabetic vascular complications is important for diagnosis and treatment. Endothelial extracellular vesicles (EVs) serve as potential intercellular communicators, transmitting biological information from the donor cell to the recipient cell, exerting both harmful and beneficial effects on vascular function. Endothelial EVs are new diagnostic and therapeutic targets and biomarkers in diabetic vascular complications. This review summarizes the biogenesis and release of endothelial EVs, as well as isolation and characterization methods, and discusses the role of endothelial EVs in the maintenance of vascular homeostasis along with their contributions to vascular dysfunction. Finally, the article illustrates the impact of endothelial EVs on the pathogenesis of diabetic vascular complications and evaluates their potential as therapeutic tools and diagnostic markers in diabetic vascular complications.
Fang et al. (Wed,) conducted a review in Diabetic vascular complications. Endothelial extracellular vesicles was evaluated. Endothelial extracellular vesicles act as intercellular communicators that exert both harmful and beneficial effects on vascular function, serving as potential diagnostic and therapeutic targets in diabetic vascular complications.
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