Key result
Extracellular vesicles derived from various cellular sources play critical roles in the pathogenesis, diagnosis, and potential treatment of diabetic retinopathy through intercellular communication.
Why the study?
A growing number of studies have revealed the potential roles of extracellular vesicles in the diagnosis and treatment of diabetic retinopathy.
Extracellular vesicles hold potential as diagnostic biomarkers and therapeutic targets for diabetic retinopathy, though their clinical application remains in its infancy.
Answers are grounded in this paper and cite their sources.
Clinical use of EVs in diabetic retinopathy remains premature; leaves open their biomarker and therapeutic potential pending prospective validation.
Extracellular vesicles (EVs) are present in almost all biological fluids and secreted by almost all cell types. A growing number of studies have revealed the potential roles of EVs in the diagnosis and treatment of the diabetic retinopathy (DR). Changes in the quantity and content of EVs may serve as biomarkers of cause or consequence of pathological status of DR, such as inflammation, neovascularization and epithelial-mesenchymal transition. In addition, as natural, safe and efficient drug carrier, EVs have been reported to play important roles in intercellular communication by acting for essential cell-specific information to target cells. In this review, we summarize the roles of EVs, secreted by various types of cells and participated in various biological processes, in the pathogenesis, diagnosis, and treatment of DR.
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Chen et al. (2023) conducted a review in Diabetic retinopathy. Extracellular vesicles (EVs) was evaluated. Extracellular vesicles derived from various cellular sources play critical roles in the pathogenesis, diagnosis, and potential treatment of diabetic retinopathy through intercellular communication.
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