This randomized trial demonstrates the biosynthetic production of olivetolic acid in Saccharomyces cerevisiae, indicating potential applications in cannabinoid synthesis.
AAE1. Together, these strategies enabled the production of 180 mg/L OA using shake flask cultures. Our results provide details of key metabolic engineering steps required for the biosynthetic production of cannabinoids and their precursors in S. cerevisiae.
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Schäfer et al. (2025) studied this question.
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