What does this research mean for the field?

Inducible cAMP early repressor (ICER) acts as a negative-feedback regulator of cardiac hypertrophy and a positive mediator of cardiac myocyte apoptosis in response to beta-adrenergic stimulation, functioning partly through the inhibition of CRE-mediated transcription and downregulation of Bcl-2. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 10, 2003Circulation ResearchOpen Access

Inducible cAMP Early Repressor (ICER) Is a Negative-Feedback Regulator of Cardiac Hypertrophy and an Important Mediator of Cardiac Myocyte Apoptosis in Response to β-Adrenergic Receptor Stimulation

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Population

Neonatal rat cardiac myocytes and rat heart in vivo

Design

Preclinical

Authors

HTHideharu TomitaShimada Municipal Hospital MNMichael NazmyAlexandria University KKKatsuya KajimotoNishikawa Hospital

Discussion

Member takes

Implication

ICER dual effects on hypertrophy-apoptosis caution targeting; leaves open therapeutic role in human remodeling.

Structured PICO

Population

Neonatal rat cardiac myocytes and rat heart in vivo

Intervention

Beta-adrenergic receptor stimulation (isoproterenol), phenylephrine, endothelin-1, and genetic manipulation of inducible cAMP early repressor (ICER) via overexpression or antisense inhibition

Outcome

Cardiac hypertrophy and cardiac myocyte apoptosissurrogate

ICER acts as a negative regulator of cardiac hypertrophy and a positive mediator of apoptosis in response to beta-adrenergic stimulation, partly through the downregulation of the antiapoptotic molecule Bcl-2.

Cite This Study

Tomita et al. (2003) studied this question.

synapsesocial.com/papers/6a0788ce3d01ce3fbe8b37fd https://doi.org/10.1161/01.res.0000079794.57578.f1

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Inducible cAMP Early Repressor (ICER) Is a Negative-Feedback Regulator of Cardiac Hypertrophy and an Important Mediator of Cardiac Myocyte Apoptosis in Response to β-Adrenergic Receptor Stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Inducible cAMP Early Repressor (ICER) Is a Negative-Feedback Regulator of Cardiac Hypertrophy and an Important Mediator of Cardiac Myocyte Apoptosis in Response to β-Adrenergic Receptor Stimulation

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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