Pulsed electric field ablation is a novel modality for cardiac arrhythmias with biophysics starkly different from radiofrequency and cryoballoon, requiring optimization of ablation parameters.
Provides an overview of the principles and biophysics of pulsed electric field ablation to aid in optimizing ablation parameters and improving procedural success.
Pulsed electric fields (PEFs) have emerged as an ideal cardiac ablation modality. At present numerous clinical trials in humans are exploring PEF as an ablation strategy for both atrial and ventricular arrhythmias, with early data showing significant promise. As this is a relatively new technology there is limited understanding of its principles and biophysics. Importantly, PEF biophysics and principles are starkly different to current energy modalities (radiofrequency and cryoballoon). Given the relatively novel nature of PEFs, this review aims to provide an understanding of the principles and biophysics of PEF ablation. The goal is to enhance academic research and ultimately enable optimization of ablation parameters to maximize procedure success and minimize risk.
Sugrue et al. (Fri,) conducted a review in Atrial and ventricular arrhythmias. Pulsed electric fields (PEFs) ablation vs. Radiofrequency and cryoballoon was evaluated. Pulsed electric field ablation is a novel modality for cardiac arrhythmias with biophysics starkly different from radiofrequency and cryoballoon, requiring optimization of ablation parameters.