Key result
Ticagrelor or prasugrel linked to reduced ischemic risk versus clopidogrel in AF patients undergoing PCI.
Why the study?
The efficacy and safety of ticagrelor or prasugrel versus clopidogrel in patients with AF on OAC undergoing PCI for MI have not been established.
Does ticagrelor or prasugrel reduce ischaemic risk compared to clopidogrel in patients with atrial fibrillation on oral anticoagulation undergoing PCI for myocardial infarction?
Observational
Does ticagrelor or prasugrel reduce ischaemic risk compared to clopidogrel in patients with atrial fibrillation on oral anticoagulation undergoing PCI for myocardial infarction?
In patients with AF on OAC undergoing PCI for MI, the use of more potent P2Y12 inhibitors (ticagrelor or prasugrel) may reduce ischemic risk without increasing bleeding risk compared to clopidogrel.
Answers are grounded in this paper and cite their sources.
May support ticagrelor or prasugrel over clopidogrel in this setting; extends RCT evidence on potent P2Y12 inhibition with OAC post-PCI.
Aims: The efficacy and safety of ticagrelor or prasugrel vs. clopidogrel in patients with atrial fibrillation (AF) on oral anticoagulation (OAC) undergoing percutaneous coronary intervention (PCI) for myocardial infarction (MI) have not been established. Methods and Conclusion: In patients with AF on OAC who underwent PCI for MI, treatment with ticagrelor or prasugrel vs. clopidogrel was associated with reduced ischaemic risk, without a concomitantly increased bleeding risk.
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Godtfredsen et al. (2023) conducted an observational in Atrial fibrillation undergoing percutaneous coronary intervention for myocardial infarction. Ticagrelor or prasugrel vs. Clopidogrel was evaluated on Ischaemic risk and bleeding risk (p== 0.69). In patients with atrial fibrillation on oral anticoagulation undergoing PCI for MI, ticagrelor or prasugrel was associated with reduced ischaemic risk compared to clopidogrel.
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